Comprehensive genomic profiling of Chinese lung cancer characterizes germline-somatic mutation interactions influencing cancer risk
This study underscores the prevalence of germline mutations in Chinese lung cancer patients, identifying significant associations with clinical characteristics and somatic mutation profiles. The findings highlight the importance of considering germline mutations in lung cancer treatment and the potential benefits of personalized therapy based on genetic susceptibility.
Authors
- Yumin Huang (ORCID: https://orcid.org/0000-0001-6355-3962)
- Ning Zhou (ORCID: https://orcid.org/0000-0002-3967-4032)
- Liang Luo (ORCID: https://orcid.org/0000-0002-1739-4996)
- Yuanyuan Xu (ORCID: https://orcid.org/0000-0001-8335-5867)
- Guoxiang Ye
- Zuodong Song
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Chest Hospital (CN)
- Sichuan Mianyang 404 Hospital (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1186/s12967-025-06096-z
- Citations
- 6
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 5.62