REG3A secreted by peritumoral acinar cells enhances pancreatic ductal adenocarcinoma progression via activation of EGFR signaling
Taken together, our data indicated that increased expression of REG3A in peritumoral acinar cells acts as a specific event to indicate PDAC progression, and verified EGFR as a possible target of REG3A, providing mechanistic insights into the role of REG3A, the diagnostic method and therapeutic strategy of PDAC.
Authors
- Yating Zhu (ORCID: https://orcid.org/0000-0002-0158-4859)
- Ying Ding (ORCID: https://orcid.org/0000-0001-5581-3058)
- Xiaodong He (ORCID: https://orcid.org/0000-0002-6682-2926)
- Xiubin Liang (ORCID: https://orcid.org/0000-0001-9169-0390)
- Xiaohang Zhou (ORCID: https://orcid.org/0000-0001-8846-1845)
- Keke Zhang (ORCID: https://orcid.org/0000-0002-5755-7059)
- Peng Sun (ORCID: https://orcid.org/0000-0002-7820-712X)
- Noriaki Maeshige (ORCID: https://orcid.org/0000-0002-3573-347X)
- Xiaojing Ren (ORCID: https://orcid.org/0000-0002-0789-8015)
- Yunfei Teng (ORCID: https://orcid.org/0000-0001-6810-6408)
- Zhijian Xu (ORCID: https://orcid.org/0000-0002-3063-8473)
- Yuege Lin
- Yi Zhang (ORCID: https://orcid.org/0000-0003-0351-5184)
- Gang Chen (ORCID: https://orcid.org/0000-0002-3490-2315)
- Kunxin Xie
- Jia Zhang (ORCID: https://orcid.org/0000-0003-1161-4836)
- Dongming Su (ORCID: https://orcid.org/0000-0003-0398-9013)
- Qingyi Liao
- Wenyu Song
Institutions
- Shanxi Medical University (CN)
- Chinese Academy of Sciences (CN)
- Shanghai Institute of Materia Medica (CN)
- Jiangsu Cancer Hospital (CN)
- Jiangsu Province Hospital (CN)
- Shanxi Academy of Medical Sciences (CN)
- Kobe University (JP)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1186/s12964-025-02103-4
- Citations
- 3
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 3.14
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China