Neuraminidase reassortment and oseltamivir resistance in clade 2.3.4.4b A(H5N1) viruses circulating among Canadian poultry, 2024

We report the detection of a clade 2.3.4.4b A(H5N1) reassortant virus with a neuraminidase surface protein derived from a North American lineage low-pathogenic avian influenza virus. This virus caused a widespread and ongoing outbreak across 45 poultry farms in British Columbia, Canada. Isolates from 8 farms reveal a mutation in the neuraminidase protein (H275Y) that is exceptionally rare among clade 2.3.4.4b viruses (present in 0.045% of publicly available clade 2.3.4.4b isolates). NA-H275Y is a well-known marker of resistance to the neuraminidase inhibitor oseltamivir. We demonstrate that this substitution maintains its resistance phenotype on the genetic background of H5N1 clade 2.3.4.4b viruses.

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Publication Details

Journal
Emerging Microbes & Infections
Published
2025-02-18
DOI
https://doi.org/10.1080/22221751.2025.2469643
Citations
22
Primary Topic
Animal Virus Infections Studies
Type
article
Field-Weighted Citation Impact
26.25

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article

Neuraminidase reassortment and oseltamivir resistance in clade 2.3.4.4b A(H5N1) viruses circulating among Canadian poultry, 2024

Cassidy N. G. Erdelyan, Charlene Ranadheera, Oliver Lung, Tomy Joseph et al.
22 citations
Emerging Microbes & Infections
Animal Virus Infections Studies
26.25
article

Neuraminidase reassortment and oseltamivir resistance in clade 2.3.4.4b A(H5N1) viruses circulating among Canadian poultry, 2024

Cassidy N. G. Erdelyan, Charlene Ranadheera, Oliver Lung, Tomy Joseph, Tamiru N. Alkie, Anthony V. Signore, Sugandha Raj, Yohannes Berhane, Nathalie Bastien, Tamiko Hisanaga, Lemarie Pama, Ifeoluwa Ayilara
article en
22 citations

Abstract

We report the detection of a clade 2.3.4.4b A(H5N1) reassortant virus with a neuraminidase surface protein derived from a North American lineage low-pathogenic avian influenza virus. This virus caused a widespread and ongoing outbreak across 45 poultry farms in British Columbia, Canada. Isolates from 8 farms reveal a mutation in the neuraminidase protein (H275Y) that is exceptionally rare among clade 2.3.4.4b viruses (present in 0.045% of publicly available clade 2.3.4.4b isolates). NA-H275Y is a well-known marker of resistance to the neuraminidase inhibitor oseltamivir. We demonstrate that this substitution maintains its resistance phenotype on the genetic background of H5N1 clade 2.3.4.4b viruses.

Emerging Microbes & InfectionsVol. 14(1)
Canadian Food Inspection Agency (CA), Public Health Agency of Canada (CA), University of Saskatchewan (CA), Ministry of Agriculture Livestock and Fisheries (KE), Ministère de l'Agriculture et de la Souveraineté alimentaire (FR), Ministry of Agriculture (CA), Agriculture and Food (AU), Ministry of Agriculture and Agro Based Industry (MY), University of Manitoba (CA), University of Guelph (CA)
Canadian Food Inspection Agency
Zero hunger
Openalex Percentile: Top 0%
Animal Virus Infections Studies
26.25
DOIOpen Access PDFOpenAlex
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