Neural Response to Food Cues in Avoidant/Restrictive Food Intake Disorder
Results indicate generalized hyperactivation of ACC, sensory association cortex, and supplementary motor cortex in response to visual food stimuli in children, adolescents, and young adults with ARFID, suggesting a novel neurobiological circuit associated with this disorder. Activation appears consistent with ARFID phenotypic rationales for food avoidance, with hyperactivation of fear regions in ARFID-fear and hypoactivation of appetite regions with increasing ARFID-lack of interest severity.
Authors
- Elisa Asanza
- Laura M. Holsen (ORCID: https://orcid.org/0000-0003-1292-7789)
- Nadia Micali (ORCID: https://orcid.org/0000-0001-5571-2273)
- Helen Burton Murray (ORCID: https://orcid.org/0000-0003-2059-3256)
- Kendra R. Becker (ORCID: https://orcid.org/0000-0002-8946-9977)
- Lilian P. Palmer (ORCID: https://orcid.org/0000-0003-3608-5395)
- Thilo Deckersbach (ORCID: https://orcid.org/0000-0001-7643-0347)
- Melissa Freizinger (ORCID: https://orcid.org/0000-0003-2160-2871)
- Jennifer J. Thomas (ORCID: https://orcid.org/0000-0003-2601-581X)
- Elana M. Bern (ORCID: https://orcid.org/0000-0003-0579-2417)
- Madhusmita Misra (ORCID: https://orcid.org/0000-0002-9405-2981)
- Julia Gydus (ORCID: https://orcid.org/0000-0002-8407-1636)
- Casey M. Stern (ORCID: https://orcid.org/0000-0002-0127-8667)
- Avery L. Van De Water (ORCID: https://orcid.org/0000-0003-3061-1964)
- Lauren Breithaupt (ORCID: https://orcid.org/0000-0002-2439-6519)
- Lydia A. Shrier (ORCID: https://orcid.org/0000-0002-9648-9319)
- Kamryn T. Eddy (ORCID: https://orcid.org/0000-0002-1586-0930)
- Elizabeth A. Lawson (ORCID: https://orcid.org/0000-0001-8619-3349)
Institutions
- Brigham and Women's Hospital (US)
- Boston Children's Hospital (US)
- Harvard University (US)
- Great Ormond Street Hospital (GB)
- Mental Health Services (DK)
- Massachusetts General Hospital (US)
- Capital Region of Denmark (DK)
- Diploma Hochschule (DE)
- University College London (GB)
- Mass General Brigham (US)
- University of Virginia (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1001/jamanetworkopen.2024.60101
- Citations
- 8
- Primary Topic
- Eating Disorders and Behaviors
- Type
- article
- Field-Weighted Citation Impact
- 18.45