Selective decline of intact HIV reservoirs during the first decade of ART followed by stabilization in memory T cell subsets
PBMCs containing intact proviral DNA are selectively lost during the first decade of suppressive ART, followed by a decade of stabilization of this reservoir in the memory T cell subsets. In the absence of clear signs of viral evolution and massive clonal expansion, homeostatic proliferation might be an important driver of HIV persistence during long-term ART.
Authors
- Monique Nijhuis (ORCID: https://orcid.org/0000-0001-6610-8282)
- Terry Huisman
- Andy I. M. Hoepelman (ORCID: https://orcid.org/0000-0001-7869-3167)
- José A. M. Borghans (ORCID: https://orcid.org/0000-0002-2931-0390)
- Jori Symons (ORCID: https://orcid.org/0000-0003-0252-3887)
- Wouter Staring (ORCID: https://orcid.org/0000-0002-7625-6083)
- Theun M. de Kort (ORCID: https://orcid.org/0000-0002-5266-8120)
- Joop E. Arends (ORCID: https://orcid.org/0000-0002-0880-0809)
- Kiki Tesselaar (ORCID: https://orcid.org/0000-0002-9847-0814)
- Lavina Gharu
- Marieke M. Nühn (ORCID: https://orcid.org/0000-0002-4360-0431)
- Rob J. de Boer (ORCID: https://orcid.org/0000-0002-2130-691X)
- Annemarie M. J. Wensing (ORCID: https://orcid.org/0000-0003-3790-8891)
- Aridaman Pandit (ORCID: https://orcid.org/0000-0003-2057-9737)
- Eduardo Lucio de Esesarte
- Kobus J. Bosman (ORCID: https://orcid.org/0000-0001-5973-5130)
- Sigrid A. Otto
- Dorien de Jong
- Ninée V.E.J. Buchholtz
Institutions
- Radboud University Nijmegen (NL)
- Utrecht University (NL)
- Maastricht University Medical Centre (NL)
- Radboud University Medical Center (NL)
- University Medical Center Utrecht (NL)
Publication Details
- Journal
- AIDS
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1097/qad.0000000000004160
- Citations
- 3
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.11