Increased Interaction between B Cells and CD3+ T Cells in Nonprogressors with Human Papillomavirus–Associated Oropharyngeal Squamous Cell Carcinoma
In human papillomavirus-associated oropharyngeal squamous cell carcinoma, immune cell subset prevalence in primary tumors differs with outcome and is associated with TTE. Interactions between B cells and both T-cell subsets are associated with longer TTE, underscoring the importance of active intratumoral immune responses in outcomes.
Authors
- Linda X. Yin (ORCID: https://orcid.org/0000-0001-8515-2051)
- Raymond M. Moore (ORCID: https://orcid.org/0000-0003-4196-1804)
- Eric J. Moore (ORCID: https://orcid.org/0000-0003-1103-6212)
- Brenna C. Novotny (ORCID: https://orcid.org/0000-0003-4732-1736)
- Kathryn M. Van Abel (ORCID: https://orcid.org/0000-0003-0513-4203)
- David M. Routman (ORCID: https://orcid.org/0000-0002-2768-003X)
- J. Daniel (ORCID: https://orcid.org/0000-0002-2957-4687)
- Kevin D. Pavelko (ORCID: https://orcid.org/0000-0001-7555-1315)
- Kathleen R. Bartemes (ORCID: https://orcid.org/0000-0003-4561-3233)
- Joaquín J. García (ORCID: https://orcid.org/0000-0002-6174-3401)
- Michael Rivera (ORCID: https://orcid.org/0000-0002-9516-2023)
- William H. Sherman
Institutions
- Mayo Clinic (US)
- WinnMed (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-2425
- Citations
- 3
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 2.09