Comparison Between Dynamic Models for Predicting Response to Corticosteroids in Alcohol‐Associated Hepatitis: A Global Cohort Study
Several dynamic models predict mortality and corticosteroid response in alcohol-associated hepatitis (AH), yet no consensus exists on the most effective model. This study aimed to assess predictive models for corticosteroid response and short-term mortality in severe AH within a global cohort. We conducted a multi-national study of patients with severe AH treated with corticosteroids for at least 7 days, enrolled between 2009 and 2019. Dynamic models-Lille-4, Lille-7, trajectory of serum bilirubin (TSB), and neutrophil-to-lymphocyte ratio (NLR)-were used to estimate 30- and 90-day mortality. Lille-7 demonstrated the highest accuracy for both 30- and 90-day mortality.
Authors
- Joaquín Cabezas (ORCID: https://orcid.org/0000-0003-0012-484X)
- Ľubomír Skladaný (ORCID: https://orcid.org/0000-0001-5171-3623)
- Patrick S. Kamath (ORCID: https://orcid.org/0000-0002-7888-1165)
- Luis Antonio Díaz (ORCID: https://orcid.org/0000-0002-8540-4930)
- Alvi H. Islam (ORCID: https://orcid.org/0000-0002-5286-4447)
- Světlana Adamcová Selčanová (ORCID: https://orcid.org/0000-0001-8181-1937)
- Meritxell Ventura‐Cots (ORCID: https://orcid.org/0000-0001-9513-2855)
- Jorge Arnold (ORCID: https://orcid.org/0000-0003-2139-5120)
- Mustafa Al‐Karaghouli (ORCID: https://orcid.org/0000-0002-0668-6002)
- Shiv Kumar Sarin (ORCID: https://orcid.org/0000-0002-0544-5610)
- Leonardo Guizzetti (ORCID: https://orcid.org/0000-0001-5864-8422)
- Winston Dunn (ORCID: https://orcid.org/0000-0002-4246-6998)
- Ramon A. Bataller (ORCID: https://orcid.org/0000-0002-1119-7799)
- Gurpreet Mahli
- Francisco Javier Idalsoaga (ORCID: https://orcid.org/0000-0001-5607-0698)
- Daniela Goyes (ORCID: https://orcid.org/0000-0002-9209-5101)
- Vijay H. Shah (ORCID: https://orcid.org/0000-0001-7620-573X)
- Juan Pablo Arab (ORCID: https://orcid.org/0000-0002-8561-396X)
- Marco A. Arrese (ORCID: https://orcid.org/0000-0002-0499-4191)
- Rokhsana Mortuza (ORCID: https://orcid.org/0000-0001-9586-9371)
- Guadalupe García‐Tsao (ORCID: https://orcid.org/0000-0001-8371-4524)
- Douglas A. Simonetto (ORCID: https://orcid.org/0000-0003-4095-8144)
- Steve Qian (ORCID: https://orcid.org/0000-0002-2840-1696)
- Heer H. Mehta (ORCID: https://orcid.org/0000-0002-5357-2112)
- Diego Rincón (ORCID: https://orcid.org/0000-0002-4470-7724)
- Mohamed A. Elfeki (ORCID: https://orcid.org/0000-0002-5623-2770)
- Daniel Ján Havaj (ORCID: https://orcid.org/0000-0001-5979-8326)
- Mohamad Ali Ibrahim (ORCID: https://orcid.org/0000-0003-0712-9993)
- Rakhi Maiwall (ORCID: https://orcid.org/0000-0003-0110-5982)
- Prasun K. Jalal (ORCID: https://orcid.org/0000-0001-5353-2324)
- Gustavo Ayares (ORCID: https://orcid.org/0000-0002-8651-2255)
- Juan G. Abraldeṣ (ORCID: https://orcid.org/0000-0003-3421-937X)
- Carolina Ramírez (ORCID: https://orcid.org/0000-0002-6805-0560)
- Ashwani Kumar Singal (ORCID: https://orcid.org/0000-0003-1207-3998)
- Karolina Sulejova
- Wei Zhang (ORCID: https://orcid.org/0000-0002-7846-8063)
- Fátima Higuera‐de‐la‐Tijera (ORCID: https://orcid.org/0000-0003-1862-7541)
Institutions
- Universitat Autònoma de Barcelona (ES)
- Western University (CA)
- Mayo Clinic (US)
- Harvard University (US)
- University of Louisville (US)
- University of Alberta (CA)
- Pontificia Universidad Católica de Chile (CL)
- Slovak Medical University (SK)
- Baylor College of Medicine (US)
- Virginia Commonwealth University (US)
- London Health Sciences Centre (CA)
- Hospital General de México (MX)
- WinnMed (US)
- Hospital General Universitario Gregorio Marañón (ES)
- Yale University (US)
- University of Florida (US)
- University of California San Diego (US)
- VA Connecticut Healthcare System (US)
- Massachusetts General Hospital (US)
- Marqués de Valdecilla University Hospital (ES)
- Instituto de Investigación Marqués de Valdecilla (ES)
- Hospital Clínic de Barcelona (ES)
- Institute of Liver and Biliary Sciences (IN)
- University of Kansas Medical Center (US)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Universidad Nacional Autónoma de México (MX)
Publication Details
- Journal
- Alimentary Pharmacology & Therapeutics
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1111/apt.70024
- Citations
- 3
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- Fondo Nacional de Desarrollo Científico y Tecnológico