Genetics, primary care records and lifestyle factors for short-term dynamic risk prediction of colorectal cancer: prospective study of asymptomatic and symptomatic UK Biobank participants
Polygenic scores contribute substantially to short-term risk prediction for CRC in both general and symptomatic populations; however, the contribution of information in primary care records (including presenting symptoms, medical history and common blood tests) is greater. Lifestyle factors not routinely collected in primary care contribute minimally.
Authors
- Samantha Ip (ORCID: https://orcid.org/0000-0001-9162-6727)
- Angela Wood (ORCID: https://orcid.org/0000-0002-7937-304X)
- Cristina Renzi (ORCID: https://orcid.org/0000-0003-3845-9493)
- Michael Lush (ORCID: https://orcid.org/0000-0001-5945-3440)
- Jonathan P. Tyrer (ORCID: https://orcid.org/0000-0003-3724-4757)
- Nora Pashayan (ORCID: https://orcid.org/0000-0003-0843-2468)
- Matthew Barclay (ORCID: https://orcid.org/0000-0003-1148-1922)
- Joe Dennis (ORCID: https://orcid.org/0000-0003-4591-1214)
- Juliet A. Usher‐Smith (ORCID: https://orcid.org/0000-0002-8501-2531)
- Hannah Harrison
- Xin Yang
- Spiros Denaxas (ORCID: https://orcid.org/0000-0001-9612-7791)
- Georgios Lyratzopoulos (ORCID: https://orcid.org/0000-0002-2873-7421)
- Antonis C Antoniou
Institutions
- Department of Health and Social Care (GB)
- Vita-Salute San Raffaele University (IT)
- University of Cambridge (GB)
- British Heart Foundation (GB)
- Lombardia Informatica (Italy) (IT)
- University College London (GB)
Publication Details
- Journal
- BMJ Oncology
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1136/bmjonc-2024-000336
- Citations
- 1
- Primary Topic
- Colorectal Cancer Screening and Detection
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Oregon Health and Science University
- UK Research and Innovation
- Cancer Research UK
- National Institute for Health and Care Research
- British Heart Foundation
- University College London
- Innovative Medicines Initiative
- Knight Cancer Institute, Oregon Health and Science University
- NIHR Cambridge Biomedical Research Centre