5-hydroxymethylfurfural attenuates osteoarthritis by upregulating of glucose metabolism in chondrocytes
Our data reveal for the first time that 5-HMF may play a role in cartilage protection in the treatment of osteoarthritis by regulating glycolysis driven by Glut1/HK1/LDHA.
Authors
- Min Qiu (ORCID: https://orcid.org/0000-0001-9493-3044)
- Kaiao Zou (ORCID: https://orcid.org/0009-0006-5047-6922)
- Jinjin Ma (ORCID: https://orcid.org/0000-0002-5446-2214)
- Pinger Wang (ORCID: https://orcid.org/0000-0002-4124-0188)
- Hongting Jin
- Yimin Yang (ORCID: https://orcid.org/0000-0003-2417-4550)
- Songfeng Hu (ORCID: https://orcid.org/0000-0002-4575-731X)
- Xinyu Wang (ORCID: https://orcid.org/0000-0003-0418-6503)
- Jiali Chen (ORCID: https://orcid.org/0000-0002-7317-4146)
- Wenhua Yuan (ORCID: https://orcid.org/0000-0002-4126-821X)
- Xixin Wang (ORCID: https://orcid.org/0000-0002-2923-3532)
- Yuanbin Zhang (ORCID: https://orcid.org/0000-0001-5137-9661)
- Xiaolong Han
- Ruogu Zhang
Institutions
- Zhejiang Chinese Medical University (CN)
- Wenzhou Hospital of Traditional Chinese Medicine (CN)
- Shaoxing People's Hospital (CN)
- First Affiliated Hospital Zhejiang University (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1016/j.phymed.2025.156499
- Citations
- 3
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 5.00
Funders
- National Natural Science Foundation of China
- Department of Health of Zhejiang Province
- Natural Science Foundation of Zhejiang Province