Psoriasis harbors multiple pathogenic type 17 T-cell subsets: Selective modulation by risankizumab
This study suggests multiple immune mechanisms of how IL-23 inhibition can modify the complex inflammatory environment present in psoriatic skin, highlighting the roles of specific T17 subsets in psoriasis development and background skin protection.
Authors
- Jongmi Lee
- Junyue Cao (ORCID: https://orcid.org/0000-0003-4097-489X)
- James G. Krueger (ORCID: https://orcid.org/0000-0002-3775-1778)
- Wei Zhou (ORCID: https://orcid.org/0000-0003-2253-1147)
- Xuan Li (ORCID: https://orcid.org/0000-0003-1768-9556)
- Jaehwan Kim (ORCID: https://orcid.org/0000-0002-7586-1425)
- Jongeun Lee (ORCID: https://orcid.org/0000-0003-4668-2329)
- Katherine Kim (ORCID: https://orcid.org/0009-0008-4500-5549)
Institutions
- VA Northern California Health Care System (US)
- Rockefeller University (US)
Publication Details
- Journal
- Journal of Allergy and Clinical Immunology
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1016/j.jaci.2025.02.008
- Citations
- 12
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 9.57
Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- National Center for Advancing Translational Sciences