A new mechanism in steroid-induced osteonecrosis of the femoral head and the protective role of simvastatin
This study demonstrates, for the first time, that glucocorticoid-induced disruptions in mitochondrial cardiolipin metabolism contribute to the pathogenesis of SONFH by inducing Cyt-c release and subsequent osteoblast apoptosis. SIM exerts a protective effect by preserving mitochondrial integrity and function, offering a potential therapeutic avenue for treating hormone-induced osteoblast damage in SONFH.
Authors
- Xiaoyi Lv (ORCID: https://orcid.org/0000-0002-8023-4119)
- Yuting Pan (ORCID: https://orcid.org/0009-0002-2553-4116)
- X. Li (ORCID: https://orcid.org/0009-0005-7539-7625)
- Xuefeng Yu (ORCID: https://orcid.org/0009-0003-8859-3241)
- Runqing Jia
- Zhe Li (ORCID: https://orcid.org/0009-0009-3725-2248)
- Dan Chen (ORCID: https://orcid.org/0000-0003-2396-0314)
- Kai‐Yun Chen (ORCID: https://orcid.org/0000-0002-2941-3197)
- Shi-da Qian
Institutions
- Nanchang University (CN)
- Beijing University of Technology (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Third Affiliated Hospital of Nanchang University (CN)
- Huizhou Central People's Hospital (CN)
- First Affiliated Hospital of University of South China (CN)
- University of South China (CN)
Publication Details
- Journal
- Experimental Cell Research
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1016/j.yexcr.2025.114471
- Citations
- 3
- Primary Topic
- Bone and Joint Diseases
- Type
- article
- Field-Weighted Citation Impact
- 5.16
Funders
- National Natural Science Foundation of China