Bioanalytical considerations for quantification of ondansetron in rat microdialysis study using LC-MS/MS
The developed LC-MS/MS method met the FDA and EMA validation criteria and was successfully applied to the in vivo pilot pharmacokinetic study. It was sensitive enough to capture the low ondansetron concentrations in brain microdialysate and universal enough to measure high ondansetron concentrations in rat serum.
Authors
- Christine N. Yohn (ORCID: https://orcid.org/0000-0002-9619-7500)
- Katarzyna Kosicka (ORCID: https://orcid.org/0000-0003-3551-4784)
- Yae Eun Chong
- Leonid Kagan (ORCID: https://orcid.org/0000-0003-3863-4757)
- Simon Haroutounian (ORCID: https://orcid.org/0000-0003-2231-5452)
- Anna Siemiątkowska (ORCID: https://orcid.org/0000-0003-3568-4716)
Institutions
- Rutgers, The State University of New Jersey (US)
- Poznan University of Medical Sciences (PL)
- Washington University in St. Louis (US)
Publication Details
- Journal
- Microchemical Journal
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1016/j.microc.2025.113082
- Citations
- 2
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- Ministerstwo Edukacji i Nauki
- Horizon 2020 Framework Programme
- National Institute of Neurological Disorders and Stroke