Effect of prenatal antibiotics on breast milk and neonatal IgA and microbiome: a case-control translational study protocol
Breast milk IgA and microbiota are critical to determine the positive effects of breastfeeding in infants. This research protocol will investigate breast milk IgA, microbiota, and the IgA<sup>+</sup> / IgA<sup>-</sup> fractions of neonatal fecal microbiota upon exposure to prenatal antibiotics. Fecal IgA and microbiota in infants exposed or not exposed to prenatal antibiotics will be analyzed up to 1 year after birth. This research will clarify the impact of prenatal antibiotics on the immune function of breast milk. This, in turn, might support the selective evaluation of breast milk IgA/microbiota in mothers exposed to prenatal antibiotics, or in donor human milk.
Authors
- Francesco D’Ambrosi (ORCID: https://orcid.org/0000-0002-5130-2266)
- Giulia Fornasa (ORCID: https://orcid.org/0000-0002-2250-7983)
- Alessandra Silvestri (ORCID: https://orcid.org/0000-0001-9179-8385)
- Lorenza Pugni (ORCID: https://orcid.org/0000-0002-7126-7277)
- Michela Lizier (ORCID: https://orcid.org/0000-0002-3173-5793)
- Carolina Carlosama (ORCID: https://orcid.org/0000-0002-8556-1231)
- Alessia Melacarne (ORCID: https://orcid.org/0000-0003-3041-344X)
- Irene Cetin (ORCID: https://orcid.org/0000-0002-9217-3034)
- Carlo Pietrasanta (ORCID: https://orcid.org/0000-0002-1019-4422)
- Monica Fumagalli (ORCID: https://orcid.org/0000-0002-0186-0710)
- Erika Carbone (ORCID: https://orcid.org/0000-0002-2013-0940)
- María Rescigno (ORCID: https://orcid.org/0000-0002-6464-509X)
- Giuseppe Penna (ORCID: https://orcid.org/0000-0003-3534-7090)
- Andrea Ronchi (ORCID: https://orcid.org/0000-0002-0966-700X)
- Fabio Mosca (ORCID: https://orcid.org/0000-0001-6477-0299)
- Enrico Maria Ferrazzi (ORCID: https://orcid.org/0000-0001-5243-0537)
- Martina Lutterotti
Institutions
- University of Siena (IT)
- Humanitas University (IT)
- University of Milan (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- IRCCS Humanitas Research Hospital (IT)
Publication Details
- Journal
- Pediatric Research
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1038/s41390-025-03922-4
- Citations
- 1
- Primary Topic
- Infant Nutrition and Health
- Type
- article
- Field-Weighted Citation Impact
- 1.12
Funders
- Ministero della Salute