Thousand and one amino acid protein kinase 1 suppression improves doxorubicin-induced cardiomyopathy by preventing cardiomyocyte death and dysfunction
Our results indicate that TAOK1 suppression is a promising therapeutic approach for treating DIC in patients with cancer and highlight the advantages of hPSC-CMs as a platform to study drug-induced cardiotoxicity.
Authors
- Satoaki Matoba (ORCID: https://orcid.org/0000-0002-9373-4331)
- Masaya Kogure
- Tomoya Kitani (ORCID: https://orcid.org/0000-0002-2696-046X)
- Takaomi Suga
- Fumiaki Ito (ORCID: https://orcid.org/0000-0002-4129-4899)
- Masataka Oishi (ORCID: https://orcid.org/0000-0002-5100-4066)
- Koji Ikeda (ORCID: https://orcid.org/0000-0002-9972-7255)
- Takehiro Ogata (ORCID: https://orcid.org/0000-0001-8044-4303)
- Atsushi Hoshino (ORCID: https://orcid.org/0000-0002-4015-1319)
Institutions
- Kyoto Prefectural University of Medicine (JP)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1093/cvr/cvaf022
- Citations
- 12
- Primary Topic
- Semiconductor materials and devices
- Type
- article
- Field-Weighted Citation Impact
- 8.77