Identification of the key role of IL-17RB in the treatment of osteoarthritis with Shaoyao Gancao decoction: Verification based on RNA-seq and bioinformatics analysis
SGD reduced the release of inflammatory factors IL-1β, IL-6 and TNF-α, upregulated COL2A1 and downregulated MMP-13 to alleviate degradation of ECM, and reduced the cartilage degeneration and progression of OA by reducing IL-17RB in articular cartilage.
Authors
- Guangcheng Wei (ORCID: https://orcid.org/0000-0001-6908-0326)
- Chengzhi Hou (ORCID: https://orcid.org/0009-0007-3842-1934)
- Ping Zhang (ORCID: https://orcid.org/0000-0002-8751-704X)
- Xuelei Chu (ORCID: https://orcid.org/0000-0002-1311-3907)
- Qinghui Song
- Yong Zhao (ORCID: https://orcid.org/0000-0003-2850-3008)
- Qiuyue Li (ORCID: https://orcid.org/0000-0003-0058-503X)
- Jialei Zhu (ORCID: https://orcid.org/0000-0002-2605-8169)
- Liping Yang (ORCID: https://orcid.org/0000-0001-6734-0884)
- Ziru Yu (ORCID: https://orcid.org/0009-0007-5259-9018)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Wangjing Hospital of China Academy of Chinese Medical Sciences (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1371/journal.pone.0315913
- Citations
- 2
- Primary Topic
- Inflammatory mediators and NSAID effects
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- National Natural Science Foundation of China