Tumor-immune partitioning and clustering algorithm for identifying tumor-immune cell spatial interaction signatures within the tumor microenvironment
Unsupervised discoveries of microgeometric tissue organizational patterns and novel tumor subtypes using the TIPC algorithm can deepen our understanding of the tumor immune microenvironment and likely inform precision cancer immunotherapy.
Authors
- Tomotaka Ugai (ORCID: https://orcid.org/0000-0003-0182-5269)
- Mai Chan Lau (ORCID: https://orcid.org/0000-0002-7698-4697)
- Jeffrey A. Meyerhardt (ORCID: https://orcid.org/0000-0002-1120-0898)
- Jennifer Borowsky (ORCID: https://orcid.org/0000-0003-3957-1364)
- Yasutoshi Takashima (ORCID: https://orcid.org/0009-0009-0430-454X)
- Melissa Zhao (ORCID: https://orcid.org/0000-0002-5190-3635)
- Koichiro Haruki (ORCID: https://orcid.org/0000-0002-1686-3228)
- Annacarolina da Silva (ORCID: https://orcid.org/0000-0002-0067-0288)
- Catherine J. Wu (ORCID: https://orcid.org/0000-0002-3348-5054)
- Charles S. Fuchs (ORCID: https://orcid.org/0000-0003-1582-9842)
- Simeng Gu (ORCID: https://orcid.org/0000-0001-5568-7063)
- Jonathan Andrew Nowak (ORCID: https://orcid.org/0000-0002-0943-7407)
- Tsuyoshi Hamada (ORCID: https://orcid.org/0000-0002-3937-2755)
- Jochen K. Lennerz (ORCID: https://orcid.org/0000-0003-2434-4978)
- Andressa Dias Costa (ORCID: https://orcid.org/0000-0003-1046-4899)
- Shuji Ogino (ORCID: https://orcid.org/0000-0002-3909-2323)
- Juha P. Väyrynen (ORCID: https://orcid.org/0000-0002-8683-2996)
- David Tai (ORCID: https://orcid.org/0000-0002-2612-0065)
- Minh N. Nguyen (ORCID: https://orcid.org/0000-0003-4949-2571)
- Joe Poh-Sheng Yeong (ORCID: https://orcid.org/0000-0002-6674-7153)
- Kota Arima
Institutions
- Broad Institute (US)
- Agency for Science, Technology and Research (SG)
- Jikei University School of Medicine (JP)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- QIMR Berghofer Medical Research Institute (AU)
- Singapore General Hospital (SG)
- Oulu University Hospital (FI)
- Singapore Immunology Network (SG)
- Addgene (US)
- Dana-Farber Cancer Institute (US)
- Duke-NUS Medical School (SG)
- Dana-Farber/Harvard Cancer Center (US)
- National Cancer Centre Singapore (SG)
- Boston Sports & Shoulder Center (US)
- Bioinformatics Institute (SG)
- University of Oulu (FI)
Publication Details
- Journal
- PLoS Computational Biology
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1371/journal.pcbi.1012707
- Citations
- 3
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 3.14
Funders
- American Association for Cancer Research
- American Cancer Society
- American Institute for Cancer Research
- Entertainment Industry Foundation
- Dana-Farber Cancer Institute
- Harvard T.H. Chan School of Public Health
- Uehara Memorial Foundation
- Mitsukoshi Health and Welfare Foundation
- Boston Biomedical
- Agency for Science, Technology and Research
- National Institutes of Health
- National Medical Research Council
- Japan Society for the Promotion of Science