Proteomic and metabolomic profiling reveals the underlying molecular mechanisms in modified alternate-day fasting-mediated protection against Diabetic kidney disease
MADF appears to mitigate the progression of DKD, with proteomic evidence pointing to lysosome-related proteins like CTSS as potential mediators of its renal protective effects. These findings indicate that MADF and the inhibition of CTSS could be considered as novel therapeutic strategies for DKD treatment.
Authors
- Yufeng Xing (ORCID: https://orcid.org/0000-0001-6762-3788)
- Yong Xu (ORCID: https://orcid.org/0000-0002-9534-6252)
- Yang Long (ORCID: https://orcid.org/0000-0003-4605-4306)
- Zongzhe Jiang (ORCID: https://orcid.org/0000-0002-1955-181X)
- MA Xiu-mei
- Xin Zeng (ORCID: https://orcid.org/0000-0001-9960-2033)
Institutions
- University of Electronic Science and Technology of China (CN)
- Affiliated Hospital of Southwest Medical University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1371/journal.pone.0319053
- Citations
- 1
- Primary Topic
- Dietary Effects on Health
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- National Natural Science Foundation of China