Performance of real-time polymerase chain reaction and Kato-Katz for diagnosing soil-transmitted helminth infections and evaluating treatment efficacy of emodepside in randomized controlled trials
Our study confirmed that qPCR is a sensitive diagnostic method for diagnosing STH infections compared to Kato-Katz and serves as a valuable tool for determining treatment efficacy in clinical trials. Furthermore, qPCR confirmed the better treatment efficacy of emodepside compared to albendazole, despite indicating lower cure rates than Kato-Katz.
Authors
- Jan Hattendorf (ORCID: https://orcid.org/0000-0002-1176-401X)
- Jennifer Keiser (ORCID: https://orcid.org/0000-0003-0290-3521)
- Christian Lotz (ORCID: https://orcid.org/0009-0004-7905-6919)
- Pierre H. H. Schneeberger (ORCID: https://orcid.org/0000-0002-8586-4937)
- Emmanuel C. Mrimi (ORCID: https://orcid.org/0000-0002-6707-7040)
- Said M. Ali
Institutions
- Ifakara Health Institute (TZ)
- Swiss Tropical and Public Health Institute (CH)
- University of Basel (CH)
- Public Health Laboratory Ivo de Carneri (TZ)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1371/journal.pntd.0012872
- Citations
- 2
- Primary Topic
- Parasites and Host Interactions
- Type
- article
- Field-Weighted Citation Impact
- 4.10
Funders
- HORIZON EUROPE European Research Council