Serum amino acid alterations in hyperuricemia: potential targets for renal disease prevention
In hyperuricemia mice, serum amino acids undergo metabolic changes. Genetically predicted UA levels are positively linked to CRF and BUN, but negatively linked to eGFRcys and eGFRcrea. Ala mediates UA's effect on CRF and BUN risk, indicating Ala could be a target for preventing renal diseases caused by hyperuricemia.
Authors
- Fu Gao (ORCID: https://orcid.org/0000-0002-9792-8248)
- Bin Geng (ORCID: https://orcid.org/0000-0001-7573-8710)
- Hongtao Lu (ORCID: https://orcid.org/0000-0002-0414-5798)
- Junfei Cheng
- S. D. Liu
- Jiahui Chen (ORCID: https://orcid.org/0000-0001-9186-1110)
- Rui Li (ORCID: https://orcid.org/0000-0002-7210-8358)
- Yuqing Ma (ORCID: https://orcid.org/0009-0007-7293-9980)
- Xiaofei Li (ORCID: https://orcid.org/0000-0003-4822-7899)
- Qinglin Sheng (ORCID: https://orcid.org/0000-0001-5836-8906)
- Fangyuan Gao (ORCID: https://orcid.org/0000-0002-2108-9185)
- Jing Wang
Institutions
- University of Shanghai for Science and Technology (CN)
- Naval University of Engineering (CN)
Publication Details
- Journal
- Amino Acids
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1007/s00726-025-03444-7
- Citations
- 1
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 1.43