TREM2 activation reduces white matter injury via PI3K/Akt/GSK‐3<i>β</i> signalling after intracerebral haemorrhage
This research is the first to illustrate that TREM2 activation mitigates WMI following ICH through a microglia-dependent mechanism involving the PI3K/Akt/GSK-3β pathway. TREM2 represents a potential therapeutic target for ICH.
Authors
- Shi You (ORCID: https://orcid.org/0000-0003-3371-9647)
- Yan Jin (ORCID: https://orcid.org/0000-0002-0378-1362)
- Qingqing Luo (ORCID: https://orcid.org/0000-0002-3401-9135)
- Yingwen Wang
- Yuan Zhang (ORCID: https://orcid.org/0000-0002-4174-0641)
- Lin Wang (ORCID: https://orcid.org/0000-0002-6449-4930)
- Lin Li (ORCID: https://orcid.org/0000-0003-3458-1045)
- Li Zhao (ORCID: https://orcid.org/0000-0003-4940-9440)
- Xiaochuan Sun (ORCID: https://orcid.org/0000-0001-6992-332X)
Institutions
- Chongqing University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Cancer Hospital (CN)
- Nanchong Central Hospital (CN)
- First People's Hospital of Chongqing (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1111/bph.17475
- Citations
- 4
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 5.56
Funders
- National Natural Science Foundation of China