Cardiovascular disease morbidity is associated with social deprivation in subjects with familial hypercholesterolaemia (FH): A retrospective cohort study of individuals with FH in UK primary care and the UK Simon Broome register, linked with national
Strikingly fewer individuals with FH are identified from lower socioeconomic groups, though the most deprived FH patients have the highest risk of CVD and mortality. In CPRD, this risk was largely explained by smoking and alcohol consumption, but not in the SB register. More effective strategies to detect FH and optimise risk factor management, are needed in lower socioeconomic groups.
Authors
- Handrean Soran (ORCID: https://orcid.org/0000-0003-1714-5014)
- Jaimini Cegla (ORCID: https://orcid.org/0000-0003-1168-0366)
- J. Schofield
- Barbara Iyen (ORCID: https://orcid.org/0000-0001-9720-1180)
- Joe Kai (ORCID: https://orcid.org/0000-0001-9040-9384)
- P.N. Durrington
- S.E. Humphries
- Nadeem Qureshi (ORCID: https://orcid.org/0000-0003-4909-0644)
- Andrew Neil (ORCID: https://orcid.org/0000-0003-0949-3748)
- Nigel Capps
Institutions
- University of Nottingham (GB)
- Wolfson Foundation (GB)
- University of Manchester (GB)
- University of Oxford (GB)
- Manchester University NHS Foundation Trust (GB)
- Shrewsbury and Telford Hospital NHS Trust (GB)
- University College London (GB)
- Imperial College London (GB)
Publication Details
- Journal
- Atherosclerosis
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1016/j.atherosclerosis.2025.119142
- Citations
- 2
- Primary Topic
- Health Promotion and Cardiovascular Prevention
- Type
- article
- Field-Weighted Citation Impact
- 3.76
Funders
- NIHR School for Primary Care Research