Total Syntheses of Antimalarial Cyclic Tetrapeptides: Koshidacins A and B via Olefin Cross-Metathesis Reactions
Abstract In this study, we present the first total syntheses of koshidacins A and B, antiplasmodial cyclic tetrapeptides from fungus, by assembling the side chain in late stage through olefin cross-metathesis. Additionally, the two diastereoisomers 8,9-epi-koshidacin A and 9-epi-koshidacin B were also synthesized by our synthetic route.
Authors
- Yuanjun Sun (ORCID: https://orcid.org/0000-0001-8035-3284)
- Liang Wang (ORCID: https://orcid.org/0000-0002-4063-6842)
- Tong Yue (ORCID: https://orcid.org/0000-0002-3330-3468)
- Yue Chen (ORCID: https://orcid.org/0000-0001-8888-1452)
- Tianhao Li (ORCID: https://orcid.org/0000-0001-5716-8320)
- Kun Yang (ORCID: https://orcid.org/0000-0002-5749-1627)
Institutions
- Nankai University (CN)
- Xi’an Jiaotong-Liverpool University (CN)
Publication Details
- Journal
- Synthesis
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1055/a-2541-6275
- Citations
- 2
- Primary Topic
- Chemical Synthesis and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 1.61