Imatinib aggravates pressure‐overload‐induced right ventricle failure via JNK/Runx2 pathway
We demonstrate for the first time that imatinib aggravates RV failure under pressure overload through JNK/Runx2 pathway, and JNK inhibition improves the therapeutic effects of imatinib on RV function in PH.
Authors
- Wenju Lu (ORCID: https://orcid.org/0000-0002-5035-9287)
- Xiaohui Zeng (ORCID: https://orcid.org/0000-0002-2353-1993)
- Qianwen Bai
- Xin Chen (ORCID: https://orcid.org/0000-0002-9905-2307)
- Lingdan Chen
- Jian Wang (ORCID: https://orcid.org/0000-0002-6991-6530)
- Zhixiong Wu
- Shanshan Wen
- Zhuoji Ma
- Liang Zhou (ORCID: https://orcid.org/0000-0003-4369-5001)
- Tao Wang (ORCID: https://orcid.org/0000-0002-7411-8218)
- Wanxian Hong
- Chunxian Cen
- Shangwei Ding (ORCID: https://orcid.org/0000-0002-9477-8758)
Institutions
- Guangzhou Institutes of Biomedicine and Health (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Zhujiang Hospital (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1111/bph.70006
- Citations
- 2
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- National Natural Science Foundation of China