Photoinduced Dearomative Multiple Functionalization of Quinolines to Construct Highly Substituted 3D Frameworks

Abstract Dearomative functionalization of quinolines expands the chemical diversity of highly functionalized 3D frameworks, such as 1,2,3,4- and 5,6,7,8-tetrahydroquinoline derivatives, which are important pharmacophores, with minimal synthetic costs. In this short review, we cover recent reports on the visible-light-induced dearomative functionalization of quinolines with an emphasis on reaction design/strategies and mechanistic studies and provide a theoretical basis for developing further dearomative syntheses in the future. 1 Introduction 2 Dearomative Functionalizations through the Formation of Photoexcited Quinolines 3 Dearomative Functionalizations through the Formation of Photoexcited Reagents/Intermediates 4 Conclusion