EBV-associated leiomyosarcoma in an immunocompromised child: A unique intracranial case with genomic study

EBV-associated smooth muscle tumors are rare but increasing in incidence among immunocompromised patients. Early recognition of EBV infection in smooth muscle tumors, especially in children with immune deficiencies, is vital for diagnosis. Histological and molecular examination, including in situ hybridization, is essential to confirm the presence of EBV. Treatment typically involves complete surgical excision, with chemotherapy's role still uncertain.