Vasorelaxant and Antihypertensive Effects of Extracts from the Leaves of Casimiroa edulis La Llave (Rutaceae) by NO Release and Calcium Channel Blockade
The results demonstrated hexane and dichloromethane extracts to exert a vasorelaxant effect through endothelium-dependent NO release and cGMP increase, as well as by calcium channel blockade. Also, dichloromethane extract showed efficacy and security as a potential antihypertensive agent.
Authors
- Luis Arias-Durán (ORCID: https://orcid.org/0000-0002-7258-7088)
- Rogélio Hernández‐Pando (ORCID: https://orcid.org/0000-0003-1292-3833)
- Samuel Estrada‐Soto (ORCID: https://orcid.org/0000-0003-1860-0744)
- Gabriela Pérez-Barrón
- Jaime Escalante (ORCID: https://orcid.org/0000-0001-5485-0244)
- Irene Perea-Arango
- Rafael Villalobos‐Pietrini
Institutions
- Universidad Autónoma de Tlaxcala (MX)
- Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (MX)
- Universidad Autónoma del Estado de Morelos (MX)
- Universidad Nacional Autónoma de México (MX)
Publication Details
- Journal
- Cardiovascular & Haematological Disorders - Drug Targets
- Published
- 2025-02-18
- DOI
- https://doi.org/10.2174/011871529x346240250211090920
- Citations
- 1
- Primary Topic
- Phytochemical compounds biological activities
- Type
- article
- Field-Weighted Citation Impact
- 0.81