Advancements in liquid marbles as an open microfluidic platform: Rapid formation, robust manipulation, and revolutionary applications

Abstract Liquid marbles (LMs) have become a focal point in microfluidics for their efficient manipulation of small liquid volumes. These non‐wetting droplets, typically coated with hydrophobic particles, offer enhanced stability, reduced evaporation and diverse utility, distinguishing them from bare droplets. This review examines advancements in LMs from 2014 to 2024, focusing on their rapid formation, robust manipulation, and revolutionary applications—termed the “3R trilogy.” We delve into the generation mechanisms, analyzing laboratory and engineering production techniques, and explore how surface particles affect LMs’ physicochemical properties. The structural dynamics and motion control of LMs are investigated, detailing their response to external forces and environmental factors. The review also highlights the state‐of‐the‐art applications of LMs in digital microfluidics, biochemical analysis, materials synthesis, environmental monitoring, soft robotics, and energy harvesting. Concluding with a discussion on significant progress and future development trends, this review provides insights and ideas for broader applications of LM‐based microfluidic platforms.