Silver‐Mediated In‐Situ Generation of Alkynyl Selenium Intramolecular AAC Click Reactions

Abstract A simple and efficient Ag‐catalyzed tandem selanylation/cyclization of o ‐alkynyl benzylazides/ o ‐alkynyloxy benzylazides with diselenides has been developed. The reaction afforded a series of 3‐seleno‐8H‐[1,2,3]triazolo[5,1‐a]isoindoles and 3‐seleno‐4 H ,10 H ‐benzo[f][1,2,3]triazolo[5,1‐c][1,4]oxazepanes in moderate to good yields. The mechanistic study revealed that the intramolecular AAC reaction of an alkynyl selenium intermediate occurred. The synthesized compound 3 k showed potent cancer cell‐growth inhibition activities.