Exploring the Clinical Value of Perioperative <scp>ctDNA</scp>‐Based Detection of Molecular Residual Disease in Patients With Esophageal Squamous Cell Carcinoma
Plasma ctDNA measured 1 month postoperatively in ESCC patients can effectively detect MRD, and ctDNA-MRD serves as an independent risk factor for postoperative recurrence. The mechanism underlying MRD positivity may involve the polarization of Tfh cells and macrophages, aiding tumor cells in immune escape through the bloodstream.
Authors
- Shuangping Zhang (ORCID: https://orcid.org/0000-0002-8321-4690)
- Jimin Li
- Yongming Song (ORCID: https://orcid.org/0000-0003-1363-8444)
- Chao Li (ORCID: https://orcid.org/0009-0004-9928-3924)
- Haibo Li (ORCID: https://orcid.org/0000-0002-6512-3912)
- Yuhui Fan
- Congcong Wu
Institutions
- Yuncheng University (CN)
- Shanxi Medical University (CN)
- Yancheng Second People's Hospital (CN)
- Yuncheng Central Hospital
Publication Details
- Journal
- Thoracic Cancer
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1111/1759-7714.70017
- Citations
- 2
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Shanxi Scholarship Council of China