Betulinic Acid Inhibits Glioma Progression by Inducing Ferroptosis Through the PI3K/Akt and NRF2/HO‐1 Pathways
BA controls the PI3K/Akt and NRF2/HO-1 pathways, which results in glioma ferroptosis. Understanding BA's multipathway mechanism may inform its therapeutic potential in glioma treatment.
Authors
- Luning Xu (ORCID: https://orcid.org/0000-0003-2647-6130)
- Xiaorong Zhou (ORCID: https://orcid.org/0000-0002-6120-7318)
- Jinxiang Huang (ORCID: https://orcid.org/0000-0002-7703-5645)
- Dezhi Kang (ORCID: https://orcid.org/0000-0002-0906-9456)
- Fang Huang (ORCID: https://orcid.org/0000-0002-2227-4761)
- Shuai Zhang (ORCID: https://orcid.org/0000-0002-3082-8744)
- Q. Li
- Hongxiang Wang (ORCID: https://orcid.org/0000-0002-7530-2906)
- Juxiang Chen
Institutions
- Fujian Medical University (CN)
- Second Military Medical University (CN)
- Changhai Hospital (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- The Journal of Gene Medicine
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/jgm.70011
- Citations
- 7
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 10.63
Funders
- Natural Science Foundation of Fujian Province