The Effectiveness and Safety of Bedaquiline, Pretomanid, and Linezolid (BPaL)–Based Regimens for Rifampicin-Resistant Tuberculosis in Non-Trial Settings—A Prospective Cohort Study in Belarus and Uzbekistan
BPaL-based regimens for MDR/RR-TB and pre-XDR-TB are safe and highly effective in non-trial settings. These regimens should be considered for widespread implementation globally, and further research is needed to evaluate their performance in other key populations.
Authors
- Varvara Solodovnikova (ORCID: https://orcid.org/0000-0003-1655-4000)
- Animesh A. Sinha (ORCID: https://orcid.org/0000-0003-3213-7813)
- Jose Luis Alvarez
- Alena Skrahina (ORCID: https://orcid.org/0000-0002-1460-0272)
- Norman Sitali (ORCID: https://orcid.org/0000-0003-2186-8530)
- Nathalie Lachenal
- Natalia Yatskevich (ORCID: https://orcid.org/0000-0001-8691-1849)
- Robert J. Klebe (ORCID: https://orcid.org/0000-0002-0722-6219)
- S. Moe (ORCID: https://orcid.org/0000-0002-2527-592X)
- Zinaida Tigay
- Nargiza Parpieva (ORCID: https://orcid.org/0000-0002-0360-1333)
- Fatimata Bintou Sall (ORCID: https://orcid.org/0000-0001-9767-6952)
- Nazgul Samieva (ORCID: https://orcid.org/0009-0008-4922-7130)
- Dzmitry Viatushka
- Sholpan Allamuratova
- Matthew J Saunders (ORCID: https://orcid.org/0000-0003-3033-2367)
- Khasan Safaev
- Muzaffar Achilov
- Corinne Merle (ORCID: https://orcid.org/0000-0003-4229-365X)
- Irina Liverko (ORCID: https://orcid.org/0000-0003-0059-9183)
- Cecilio Tan
- A. Khristusev
- Camilo Gomez Restrepo
- Michael L. Rekart
- Sanjar Mirzabaev
Institutions
- Médecins Sans Frontières (UG)
- St George's, University of London (GB)
- World Health Organization (CH)
- Wuhan Pulmonary Hospital (CN)
- Republican Scientific and Practical Centre of Pulmonology and Tuberculosis (BY)
- Médecins Sans Frontières (GB)
- Médecins Sans Frontières (CH)
- Médecins Sans Frontières (US)
- Tashkent Pediatric Medical Institute (UZ)
- City St George's, University of London (GB)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1093/cid/ciaf035
- Citations
- 8
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 11.17
Funders
- Global Fund to Fight AIDS, Tuberculosis and Malaria
- Médecins Sans Frontières