Prognosis of p16 and Human Papillomavirus Discordant Oropharyngeal Cancers and the Exploration of Using Natural Language Processing to Analyze Free-Text Pathology Reports
NLP classified head and neck cancer pathology reports with high concordance with gold-standard categorization, but a conspicuous portion of reports could not be interpreted. p16/HPV discordant OPC constitutes a noteworthy minority of patients. The inferior prognosis of p16+/HPV- suggests that p16 alone for prognostication is insufficient-especially when considering treatment de-escalation.
Authors
- Tony Hung (ORCID: https://orcid.org/0000-0002-3872-5512)
- Nadeem Riaz (ORCID: https://orcid.org/0000-0001-9873-5862)
- Yao Yu (ORCID: https://orcid.org/0000-0002-2814-4482)
- Ethan Shin
- Chester Poon (ORCID: https://orcid.org/0000-0001-6931-2414)
- Justin Choi (ORCID: https://orcid.org/0009-0003-3866-8719)
- Jung Julie Kang (ORCID: https://orcid.org/0000-0001-9773-5481)
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- SUNY Downstate Health Sciences University (US)
- Yale University (US)
- Geneva College (US)
Publication Details
- Journal
- JCO Clinical Cancer Informatics
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1200/cci-24-00177
- Citations
- 1
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.85