IL-36–driven pustulosis: Transcriptomic signatures match between generalized pustular psoriasis (GPP) and acute generalized exanthematous pustulosis (AGEP)
We propose that AGEP is a drug-induced variant of GPP and therefore part of IL-36-related pustulosis. A key signature overarching this spectrum was identified, thereby opening the therapeutic approach of IL-36 inhibition to all subtypes of the disease.
Authors
- Johannes Woltsche (ORCID: https://orcid.org/0000-0002-2240-6736)
- Andrea Szegedi (ORCID: https://orcid.org/0000-0003-2109-9014)
- Eva Schadelbauer (ORCID: https://orcid.org/0000-0001-6110-520X)
- Thomas Graier (ORCID: https://orcid.org/0000-0002-3007-7776)
- Gudrun Ratzinger (ORCID: https://orcid.org/0000-0002-9860-6697)
- Barbara Meier (ORCID: https://orcid.org/0000-0003-2807-5066)
- Alexander A. Navarini (ORCID: https://orcid.org/0000-0001-7059-632X)
- Adam Reich (ORCID: https://orcid.org/0000-0002-5573-1754)
- Peter Wolf (ORCID: https://orcid.org/0000-0001-7777-9444)
- Natalie Bordag (ORCID: https://orcid.org/0000-0002-9505-6271)
- Marta Kołt‐Kamińska
- Romana Čeović (ORCID: https://orcid.org/0000-0002-1296-6174)
- Valeria Mateeva (ORCID: https://orcid.org/0000-0002-4694-4977)
- Julia‐Tatjana Maul (ORCID: https://orcid.org/0000-0002-9914-1545)
- Theresa Benezeder (ORCID: https://orcid.org/0000-0001-6218-2792)
- Damian Meyersburg (ORCID: https://orcid.org/0000-0001-8339-6917)
- Maruška Marovt (ORCID: https://orcid.org/0000-0003-1954-1416)
- Herwig Zach
- Katharina Falkensteiner (ORCID: https://orcid.org/0000-0002-8044-2727)
- Lorenzo Cerroni (ORCID: https://orcid.org/0009-0001-9971-6927)
- Lev Pavlovksy
- Knut Prillinger
- Maria Sanzharovskaja
Institutions
- University of Debrecen (HU)
- University Hospital Centre Zagreb (HR)
- Innsbruck Medical University (AT)
- Tel Aviv University (IL)
- University of Zagreb (HR)
- Universität Innsbruck (AT)
- Medical University of Graz (AT)
- University of Zurich (CH)
- Paracelsus Medical University (AT)
- Rabin Medical Center (IL)
- University Hospital of Basel (CH)
- Medical University of Sofia (BG)
- University Hospital of Zurich (CH)
- Universitätsklinikum St. Pölten (AT)
- Boehringer Ingelheim (Austria) (AT)
- University Clinical Centre Maribor (SI)
- University of Rzeszów (PL)
Publication Details
- Journal
- Journal of Allergy and Clinical Immunology
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1016/j.jaci.2025.01.046
- Citations
- 22
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 17.54