Subtherapeutic Meropenem Antibiotic Exposure in Children With Septic Shock Assessed by Noncompartmental Pharmacokinetic Analysis in a Prospective Dataset
Given the variability in meropenem systemic exposure in pediatric septic shock, therapeutic drug monitoring, or monitoring for ARC, is suggested during the first days of hospitalization to allow daily assessments of dosing needs to achieve pharmacodynamic exposure targets for sepsis.
Authors
- John S. Bradley (ORCID: https://orcid.org/0000-0002-3835-5064)
- T. J. Jones (ORCID: https://orcid.org/0000-0002-8716-6980)
- Edmund V. Capparelli (ORCID: https://orcid.org/0000-0002-1630-0505)
- Sean N. Avedissian (ORCID: https://orcid.org/0000-0002-0935-6455)
- Jeremiah D. Momper (ORCID: https://orcid.org/0000-0002-3154-6685)
- Jennifer Lê (ORCID: https://orcid.org/0000-0002-6692-0884)
- Douglas H. Jones (ORCID: https://orcid.org/0000-0002-7812-9125)
- Robert H. Mak (ORCID: https://orcid.org/0000-0002-8512-9000)
- Helen Harvey (ORCID: https://orcid.org/0000-0001-5835-9575)
- D. M. STOUT
- Courtney Barbato
Institutions
- Nebraska Medical Center (US)
- Godfrey Okoye University (NG)
- University of California San Diego (US)
- Rady Children's Hospital-San Diego (US)
- University of Nebraska Medical Center (US)
- University of Montana (US)
Publication Details
- Journal
- Pediatric Critical Care Medicine
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1097/pcc.0000000000003698
- Citations
- 2
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 2.79