Subcutaneous Infection Resulting From the Migration of a Peripherally Inserted Central Catheter Into the Angular Vein

Background: Peripherally inserted central catheter (PICC) migration into smaller veins is rare, often recognized only when catheter dysfunction occurs or associated clinical complications manifest. This study aims to highlight subcutaneous tissue infections as an unusual complication of PICC migration in newborns.Case Presentation: We report a case of a newborn male who experienced PICC migration into the angular vein after a prior successful repositioning. Factors contributing to this migration include anatomical variations in the venous system, left-sided catheter insertion, the need for mechanical ventilation due to persistent pulmonary hypertension of the newborn, and the potential influence of using a 2 Fr diameter PICC line.Conclusion: Maintaining detailed documentation of the external catheter length and conducting regular imaging post-PICC placement is crucial, especially if the patient shows signs of catheter dysfunction or if unanticipated complications develop.