Polyol-modified deformable liposomes fortified contact lenses for improved ocular permeability
Nano-vesicles resulted in size and deformability index of 200.5 ± 15 nm and 11.58, respectively, with entrapment efficiency of 80.98% of the drug. Moreover, the optimized lenses demonstrated 71%) of swelling and transmittance of 87%). In addition, <i>in vitro</i> release of active component from the therapeutic contact lens demonstrated sustained drug release over 24 h. Whereas <i>ex vivo</i> studies displayed a 5-fold increase in drug permeation, compared to tested conventional eye drops. The results suggested that glycerosomes-loaded contact lens can be a promising alternative for regulated delivery of dexamethasone sodium phosphate in the management of posterior uveitis.
Authors
- Jeel Dave
- Abhijeet Puri
- Sony Priyanka Bandi (ORCID: https://orcid.org/0000-0002-5252-336X)
- Popat Mohite (ORCID: https://orcid.org/0000-0002-4536-4444)
- Ketan M. Ranch (ORCID: https://orcid.org/0000-0003-3865-8855)
- Vijay R. Chidrawar
- Sudarshan Singh
- Deepanjan Datta (ORCID: https://orcid.org/0000-0001-8398-4276)
- Harshilkumar Jani (ORCID: https://orcid.org/0009-0007-2616-8265)
- Y. Patel
Institutions
- Manipal Academy of Higher Education (IN)
- Narsee Monjee Institute of Management Studies (IN)
- Gujarat Technological University (IN)
- Chiang Mai University (TH)
- B.J. Medical College (IN)
- Birla Institute of Technology and Science, Pilani (IN)
Publication Details
- Journal
- Nanomedicine
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1080/17435889.2025.2463867
- Citations
- 11
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 20.66