Multiomic Analysis of Calf Muscle in Peripheral Artery Disease and Chronic Kidney Disease
CKD significantly exacerbates ischemic muscle pathology in PAD, as evidenced by diminished muscle strength, reduced mitochondrial function, and altered transcriptome profiles. The correlation between uremic toxins and muscle dysfunction suggests that targeting these metabolites may offer therapeutic potential for improving muscle health in PAD patients with CKD.
Authors
- Victoria R. Palzkill (ORCID: https://orcid.org/0000-0001-9382-169X)
- Scott A. Berceli (ORCID: https://orcid.org/0000-0003-2257-0111)
- Trace Thome (ORCID: https://orcid.org/0000-0003-4823-8547)
- Brian J. Fazzone (ORCID: https://orcid.org/0000-0002-8987-1480)
- TERENCE EDWARD RYAN (ORCID: https://orcid.org/0000-0003-0780-029X)
- Nicholas Vugman
- Salvatore T. Scali (ORCID: https://orcid.org/0000-0002-8128-3203)
- Kyoungrae Kim (ORCID: https://orcid.org/0000-0001-9513-6469)
- Erik Anderson (ORCID: https://orcid.org/0000-0001-8957-5932)
- Caroline G. Pass (ORCID: https://orcid.org/0009-0003-4234-8777)
- Feng Yue (ORCID: https://orcid.org/0000-0002-5856-3506)
- Qingping Yang (ORCID: https://orcid.org/0000-0002-6261-7861)
- Lauren Stone
- Kerri A. O’Malley
Institutions
- University of Florida (US)
- Institut de Myologie (FR)
- Norwegian Womens Public Health Association (NO)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1161/circresaha.124.325642
- Citations
- 7
- Primary Topic
- Peripheral Artery Disease Management
- Type
- article
- Field-Weighted Citation Impact
- 14.04