<i>TAX1BP3</i> Causes TRPV4-Mediated Autosomal Recessive Arrhythmogenic Cardiomyopathy

We conclude that <i>TAX1BP3</i> is associated with rare autosomal recessive ACM through TRPV4-mediated Ca<sup>2+</sup> leak from RyR2. Further, TRPV4 current inhibition has the potential to be a new therapeutic target for ACM.

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Publication Details

Journal
Circulation Research
Published
2025-02-18
DOI
https://doi.org/10.1161/circresaha.124.325180
Citations
4
Primary Topic
Cardiovascular Effects of Exercise
Type
article
Field-Weighted Citation Impact
5.55
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article

TAX1BP3 Causes TRPV4-Mediated Autosomal Recessive Arrhythmogenic Cardiomyopathy

Andrew Paul Landstrom, Paul C. Tang, Qixin Yang, Heidi Cope et al.
4 citations
Circulation Research
Cardiovascular Effects of Exercise
5.55
article

TAX1BP3 Causes TRPV4-Mediated Autosomal Recessive Arrhythmogenic Cardiomyopathy

Andrew Paul Landstrom, Paul C. Tang, Qixin Yang, Heidi Cope, Catherine Rehder, Leonie M. Kurzlechner, Hugh G Calkins, Jordan E. Ezekian, Enya R. Dewars, Amy M. Berkman, Padmapriya Muralidharan, TV Asokan, Zhushan Zhang, Zebulon Z. Spector, A SALA, Michael J. Campbell, Bo Sun, Mike Sullivan, Robin M. Perelli, Mary E. Moya‐Mendez, Andrew Breglio, Vandana Shashi, Cynthia A. James, Alexander S. Behura, Anna Ponek, Gabrielle Monaco
article en
4 citations

Abstract

We conclude that <i>TAX1BP3</i> is associated with rare autosomal recessive ACM through TRPV4-mediated Ca<sup>2+</sup> leak from RyR2. Further, TRPV4 current inhibition has the potential to be a new therapeutic target for ACM.

Circulation ResearchVol. 136(7)
MACOM (United States) (US), Johns Hopkins University (US), Duke University (US), University of Michigan (US), Johns Hopkins Bayview Medical Center (US), Southwestern Medical Center (US), Duke Medical Center (US), Duke University Health System (US), The University of Texas Southwestern Medical Center (US)
Good health and well-being
Openalex Percentile: Top 5%
Cardiovascular Effects of Exercise
5.55
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