Cover Feature: Recombinant Production of The Cyclotide Kalata B1 by Conditional Split Inteins (ChemBioChem 4/2025)

This illustration represents the facile scalability and ease of operation of a workflow designed for the mass production of cyclotides from recombinantly expressed split inteins. Conversion of precursor proteins, easily produced and purified from E. coli, proceeds by simply mixing two fragments of a split intein to yield the desired cyclic peptide. More information can be found in the article 10.1002/cbic.202400591 by David J. Craik and co-workers. Cover art designed by Dr Peta J. Harvey.