Cover Feature: Synthesis of Substituted Acyclic and Cyclic <i>N</i>‐Alkylhydrazines by Enzymatic Reductive Hydrazinations (ChemBioChem 4/2025)

The imine reductase (IRED) from Myxococcus stipitatus catalyses the reductive amination of structurally diverse carbonyls and dicarbonyls with hydrazines (reductive hydrazination), which are also known as rocket fuels. This efficient process produces acyclic and cyclic N-alkylhydrazines, demonstrating the scalability and potential of IREDs for sustainable ′green′ chemical synthesis using H₂ as the reducing agent. More information can be found in the article 10.1002/cbic.202400700 by Lars Lauterbach, Bettina M. Nestl and co-workers. Illustration by Lutz Kupferschläger.