Targeting PGE2 mediated senescent neuron improves tumor therapy
Our study revealed that the AEP/PGE2 feedback loop modulates tumor-induced neuronal senescence upon radio-/chemotherapy and highlights the therapeutic value to improve tumor therapy.
Authors
- Renhua Huang (ORCID: https://orcid.org/0000-0001-6384-9480)
- Xi Huang (ORCID: https://orcid.org/0000-0002-6871-4099)
- Shukai Lin
- Gang Cai (ORCID: https://orcid.org/0000-0001-5465-7532)
- Jianyi Zhao
- Yingying Lin (ORCID: https://orcid.org/0000-0002-6935-5681)
- Linshi Wu (ORCID: https://orcid.org/0000-0002-5117-7274)
- Jian Yang (ORCID: https://orcid.org/0000-0003-3033-1161)
- Jiayi Chen (ORCID: https://orcid.org/0000-0002-1058-8771)
- Juxiang Chen (ORCID: https://orcid.org/0000-0002-5171-9707)
- Lu Cao (ORCID: https://orcid.org/0000-0001-9307-5092)
- Li Zhou (ORCID: https://orcid.org/0000-0003-0539-3467)
- Dan Ou (ORCID: https://orcid.org/0000-0001-6427-4199)
- Qi Lv (ORCID: https://orcid.org/0000-0001-8798-0758)
- Keman Liao
Institutions
- Tongji University (CN)
- Guangxi Medical University (CN)
- Second Military Medical University (CN)
- Renji Hospital (CN)
- Ruijin Hospital (CN)
- Shanghai Genon Biological Products (China) (CN)
- Changhai Hospital (CN)
- Sanya Central Hospital (CN)
- Tumor Hospital of Guangxi Medical University (CN)
- Tongji Hospital (CN)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1093/neuonc/noaf045
- Citations
- 7
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 6.55