DNA methylation status classifies pleural mesothelioma cells according to their immune profile: implication for precision epigenetic therapy
The study highlighted the relevance of DNA methylation in shaping the constitutive immune classification of PM cells, independent of their histological subtypes. The identified role of DHA in shifting the phenotype of PM cells towards an immune-favorable state highlights its potential for evaluation in phase I/II clinical trials investigating the efficacy of epigenetic-based ICI combinations to reverse cancer immune resistance mechanisms.
Authors
- Andrea Anichini (ORCID: https://orcid.org/0000-0001-5096-5538)
- Alessia Covre (ORCID: https://orcid.org/0000-0001-8721-5693)
- Luana Calabrò (ORCID: https://orcid.org/0000-0002-3044-0889)
- Michele Maio (ORCID: https://orcid.org/0000-0002-0323-6321)
- Rossella Tufano (ORCID: https://orcid.org/0000-0002-9158-3533)
- Teresa Noviello (ORCID: https://orcid.org/0000-0002-3411-6752)
- Francesca Piazzini (ORCID: https://orcid.org/0009-0001-6371-6570)
- Fabrizio Celesti (ORCID: https://orcid.org/0000-0003-1629-0922)
- Maria Fortunata Lofiego (ORCID: https://orcid.org/0009-0009-4800-2084)
- Roberta Mortarini (ORCID: https://orcid.org/0000-0001-7732-0561)
- Laura Solmonese (ORCID: https://orcid.org/0000-0003-3662-386X)
- Francesco Marzani (ORCID: https://orcid.org/0009-0005-9399-4511)
- Michele Ceccarelli (ORCID: https://orcid.org/0000-0002-4702-6617)
- Francesca Pia Caruso (ORCID: https://orcid.org/0000-0002-2206-1459)
- Sandra Coral (ORCID: https://orcid.org/0000-0002-1308-3082)
- Anna Maria Di Giacomo
- Emma Bello (ORCID: https://orcid.org/0009-0006-3358-9327)
Institutions
- University of Siena (IT)
- University of Miami (US)
- University of Ferrara (IT)
- Biogem (IT)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Sylvester Comprehensive Cancer Center (US)
- University of Naples Federico II (IT)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1186/s13046-025-03310-0
- Citations
- 2
- Primary Topic
- Occupational and environmental lung diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- Ministero della Salute
- Associazione Italiana per la Ricerca sul Cancro