<i>In silico</i> study of selected alkaloids as dual inhibitors of β- and γ-secretases for Alzheimer's disease
This study suggests that demissidine, solasodine, tomatidine, and solanidine are promising dual inhibitors against β- and γ-secretase proteins <i>in silico</i>. However, there is an urgent need to carry out in vitro and in vivo experiments on these new leads to validate the findings of this study.
Authors
- Aeshah A. Awaji
- Dorcas Oladayo Fatoba (ORCID: https://orcid.org/0000-0002-8500-2018)
- Ridwan Opeyemi Bello (ORCID: https://orcid.org/0000-0002-6095-5883)
- Nike Idowu (ORCID: https://orcid.org/0000-0002-1730-4604)
- Haruna Isiyaku Umar (ORCID: https://orcid.org/0000-0001-9427-9804)
- Abdullahi Tunde Aborode (ORCID: https://orcid.org/0000-0003-2516-5920)
- Sodiq Fakorede (ORCID: https://orcid.org/0000-0001-7717-105X)
- Isreal Ayobami Onifade (ORCID: https://orcid.org/0000-0002-8062-5873)
- Bunmi Helen Adeleye
- Ifeoluwapo Deborah Jegede (ORCID: https://orcid.org/0009-0006-2020-5734)
Institutions
- Albany State University (US)
- University of Nebraska–Lincoln (US)
- University of Huddersfield (GB)
- University of Tennessee Health Science Center (US)
- The University of Queensland (AU)
- Federal University of Technology (NG)
- University at Albany, State University of New York (US)
- University of Kansas Medical Center (US)
- Syracuse University (US)
- University of Tabuk (SA)
Publication Details
- Journal
- Journal of Alzheimer s Disease
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1177/13872877241313049
- Citations
- 2
- Primary Topic
- Cholinesterase and Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.79