Structural covariance network patterns linked to neuropsychiatric symptoms in biologically defined Alzheimer's disease: Insights from the mild behavioral impairment checklist
This study reveals associations between MBI subdomains and structural brain network alterations in biologically-confirmed AD. The IFG's involvement is crucial for mood dysregulation, while the PCC could be involved in compensatory mechanisms for social cognition and impulse control. These findings underscore the significance of biomarker-based neuroimaging for the characterization of NPS across the AD spectrum.
Authors
- Alessia Giugno (ORCID: https://orcid.org/0000-0002-9366-1582)
- Salvatore Nigro (ORCID: https://orcid.org/0000-0001-7566-7983)
- Daniele Urso (ORCID: https://orcid.org/0000-0002-4503-0110)
- Paolo Manganotti (ORCID: https://orcid.org/0000-0001-5305-6268)
- Benedetta Tafuri (ORCID: https://orcid.org/0000-0002-2931-6039)
- Giancarlo Logroscino (ORCID: https://orcid.org/0000-0003-0423-3242)
- Davide Vilella (ORCID: https://orcid.org/0009-0008-5319-7050)
- Valentina Gnoni (ORCID: https://orcid.org/0000-0003-3181-0842)
- Maria Teresa Dell’Abate (ORCID: https://orcid.org/0000-0003-3364-5721)
- Marco Michelutti (ORCID: https://orcid.org/0009-0009-4308-8456)
- Chiara Zecca (ORCID: https://orcid.org/0000-0002-7855-5714)
- Roberto De Blasi (ORCID: https://orcid.org/0000-0002-8556-8572)
Institutions
- University of Trieste (IT)
- King's College London (GB)
- Istituto di Nanotecnologia (IT)
- National Research Council (IT)
- University of Bari Aldo Moro (IT)
Publication Details
- Journal
- Journal of Alzheimer s Disease
- Published
- 2025-02-16
- DOI
- https://doi.org/10.1177/13872877251316794
- Citations
- 3
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.29