Trimethylamine N‐oxide induces pyroptosis in HTR8‐S/Vneo cells through the ten‐eleven translocation 2‐cytochrome b‐reactive oxygen species pathway
In summary, these findings suggest that TMAO induces pyroptosis in HTR8/SVneo cells through the TET2-CYTB-mtROS pathway, contributing to mitochondrial dysfunction and inflammation. The significant elevation of TMAO levels in PE placental tissues further supports its role in the pathophysiology of PE. Targeting the TET2-CYTB-mtROS pathway may provide a novel therapeutic strategy for the treatment of PE.
Authors
- Lingli Liang (ORCID: https://orcid.org/0000-0002-5753-0358)
- Peng Wu (ORCID: https://orcid.org/0000-0002-7440-074X)
- Jingjing Wang (ORCID: https://orcid.org/0000-0002-1491-5047)
- Jun Meng (ORCID: https://orcid.org/0000-0002-7633-3624)
- Zuo Wang
- Lu He (ORCID: https://orcid.org/0000-0002-7367-2452)
- Yuzhu Rao (ORCID: https://orcid.org/0009-0006-4923-247X)
- Jinli Zhao
Institutions
- Central South University (CN)
- First Affiliated Hospital of University of South China (CN)
- Hengyang Academy of Agricultural Sciences (CN)
- Xiangya Hospital Central South University (CN)
- University of South China (CN)
Publication Details
- Journal
- Journal of obstetrics and gynaecology research
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1111/jog.16237
- Citations
- 1
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 2.06
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province