Study on the Mechanisms of Ischemic Stroke Impacting Sleep Homeostasis and Circadian Rhythms in Rats
IS can lead to neurological impairments and brain damage, with aged rats showing more severe effects. IS also disturbs melatonin and cortisol levels, affects sleep homeostasis, and results in disordered Per1 and Cry1 gene and protein expression levels. These findings underscore the role of circadian disruption and stress response in the pathology of IS, especially in aging populations.
Authors
- Yong‐Hui Zheng (ORCID: https://orcid.org/0000-0002-1098-7385)
- Chen Sun (ORCID: https://orcid.org/0009-0005-2889-1882)
- Tingting Chu
- Lin‐lin Zhao
- Jingyu Zhang (ORCID: https://orcid.org/0000-0002-9507-3223)
- Wei Gao (ORCID: https://orcid.org/0000-0002-7426-1874)
Institutions
- Harbin Medical University (CN)
- Fourth Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1111/cns.70153
- Citations
- 6
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 5.49