Panaxadiol Attenuates Neuronal Oxidative Stress and Apoptosis in Cerebral Ischemia/Reperfusion Injury via Regulation of the <scp>JAK3</scp>/<scp>STAT3</scp>/<scp>HIF</scp>‐1α Signaling Pathway

PD significantly counteracts CIS/CIRI by modulating the JAK3/STAT3/HIF-1α signaling pathway, making it a promising therapeutic agent for treating CIS/CIRI.

Authors

Dongye Yi (ORCID: https://orcid.org/0000-0001-9684-132X)
Yuhan Liu (ORCID: https://orcid.org/0000-0001-8590-2297)
Shilin Zhang (ORCID: https://orcid.org/0000-0002-5872-3418)
Lei Yu (ORCID: https://orcid.org/0000-0002-7329-4631)
Jiabin Zhou (ORCID: https://orcid.org/0000-0003-2262-866X)

Institutions

Union Hospital (HK)
Wuhan University (CN)
Integrated Chinese Medicine (China) (HK)
Chinese People's Liberation Army (CN)
Huazhong University of Science and Technology (CN)

Publication Details

Journal: CNS Neuroscience & Therapeutics
Published: 2025-02-01
DOI: https://doi.org/10.1111/cns.70233
Citations: 4
Primary Topic: Ginseng Biological Effects and Applications
Type: article
Field-Weighted Citation Impact: 3.22

Funders

Natural Science Foundation of Hubei Province

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article

Panaxadiol Attenuates Neuronal Oxidative Stress and Apoptosis in Cerebral Ischemia/Reperfusion Injury via Regulation of the JAK3/STAT3/HIF‐1α Signaling Pathway

Dongye Yi, Yuhan Liu, Shilin Zhang, Lei Yu et al.

Feb 1, 2025

4 citations

CNS Neuroscience & Therapeutics

Ginseng Biological Effects and Applications

3.22

article

Panaxadiol Attenuates Neuronal Oxidative Stress and Apoptosis in Cerebral Ischemia/Reperfusion Injury via Regulation of the JAK3/STAT3/HIF‐1α Signaling Pathway

Dongye Yi, Yuhan Liu, Shilin Zhang, Lei Yu, Jiabin Zhou

February 1, 2025article en

4 citations

Abstract

PD significantly counteracts CIS/CIRI by modulating the JAK3/STAT3/HIF-1α signaling pathway, making it a promising therapeutic agent for treating CIS/CIRI.

CNS Neuroscience & TherapeuticsVol. 31(2)

Union Hospital (HK), Wuhan University (CN), Integrated Chinese Medicine (China) (HK), Chinese People's Liberation Army (CN), Huazhong University of Science and Technology (CN)

Natural Science Foundation of Hubei Province

Openalex Percentile: Top 9%

Ginseng Biological Effects and Applications

3.22

DOI Open Access PDF OpenAlex

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Panaxadiol Attenuates Neuronal Oxidative Stress and Apoptosis in Cerebral Ischemia/Reperfusion Injury via Regulation of the <scp>JAK3</scp>/<scp>STAT3</scp>/<scp>HIF</scp>‐1α Signaling Pathway — Dongye Yi, Yuhan Liu, et al. · CNS Neuroscience & Therapeutics (2025) | TGRS Research Map | TGRS