Berberine Derivative B68 Promotes Tumor Immune Clearance by Dual‐Targeting BMI1 for Senescence Induction and CSN5 for PD‐L1 Degradation (Adv. Sci. 7/2025)
Berberine Derivative B68 Promotes Tumor Immune Clearance In article number 2413122, Hanchen Xu, Bo Li, Weidong Zhang, Sanhong Liu, and co‐workers introduce B68, a berberine derivative, as a dual‐targeting cancer treatment. It targets BMI1 to induce senescence and halt tumor growth, and CSN5 to degrade PD‐L1, enhancing T‐cell attacks on cancer cells. The cover art, inspired by Hou Yi shooting down the suns, symbolizes these dual actions, offering hope for treating colorectal and other cancers. [Image: see text]
Authors
- Hongmei Hu
- Xu‐Wen Li (ORCID: https://orcid.org/0000-0001-7919-9726)
- Qing Zhang (ORCID: https://orcid.org/0009-0003-6048-203X)
- Sai Tian (ORCID: https://orcid.org/0000-0003-2498-190X)
- Mengting Xu (ORCID: https://orcid.org/0000-0002-6751-1986)
- Hanchen Xu
- Sanhong Liu (ORCID: https://orcid.org/0000-0002-8695-0343)
- Xiaoyu Tao (ORCID: https://orcid.org/0009-0000-0634-6254)
- Linyang Li (ORCID: https://orcid.org/0009-0005-4892-6253)
- Dianping Yu
- Bo Li (ORCID: https://orcid.org/0000-0003-1628-8128)
- Hongwei Zhang (ORCID: https://orcid.org/0000-0002-9971-4518)
- Weidong Zhang (ORCID: https://orcid.org/0000-0002-7384-2490)
- Weiliang Zhu (ORCID: https://orcid.org/0000-0002-1024-4389)
- Mengmeng Guo (ORCID: https://orcid.org/0000-0002-7606-4954)
- Kaixian Chen
- Hanchi Xu
- Xiangxin Geng
- Shuhua Xie (ORCID: https://orcid.org/0009-0002-8500-2023)
- Qun Wang (ORCID: https://orcid.org/0000-0003-1014-8677)
Publication Details
- Journal
- Advanced Science
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/advs.202570038
- Primary Topic
- Berberine and alkaloids research
- Type
- article
- Field-Weighted Citation Impact
- 0.00