Cover Feature: Design, Synthesis, and Anti‐Prostate Cancer Potential of 2‐(4‐Nitrobenzyl) Malonates <i>In Vitro</i> and DAL Acute Oral Toxicity Assessment <i>In Vivo</i> (ChemMedChem 4/2025)
2-[(4-Nitrophenyl)methyl]propanedioates and 2-[(4-aminophenyl)methyl]propanedioates were synthesized with malonates and 4-nitrobenzyl bromide as starting materials. The six compounds were spectrophotometrically characterized post-purification and evaluated for their antioxidant, anti-inflammatory, and anticancer properties with a variety of assays. The most potent compound 3c was evaluated for its efficacy in vivo in a Dalton Ascites Lymphoma murine model and evaluated computationally for its apoptosis-inducing abilities. More details can be found in article 10.1002/cmdc.202400371 by Simone Carradori, Prasanna Ramani, and co-workers.
Authors
- Prasanna Ramani (ORCID: https://orcid.org/0000-0002-5236-7141)
- Bharathi Hassan Ganesh (ORCID: https://orcid.org/0009-0000-9416-6623)
- Himabindu Padinjarathil (ORCID: https://orcid.org/0000-0002-1073-9963)
- Simone Carradori (ORCID: https://orcid.org/0000-0002-8698-9440)
- Srikrishna Mudradi (ORCID: https://orcid.org/0000-0002-8460-1801)
- Baladhandapani Aruchamy (ORCID: https://orcid.org/0000-0002-3826-7654)
- Sarthak Mohanty (ORCID: https://orcid.org/0000-0001-5638-6529)
Institutions
- University of Chieti-Pescara (IT)
- Amrita Vishwa Vidyapeetham (IN)
Publication Details
- Journal
- ChemMedChem
- Published
- 2025-02-16
- DOI
- https://doi.org/10.1002/cmdc.202580402
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.00