Micro‐Determination of the Macro‐Drugs (Pseudoephedrine Hydrochloride‐Ibuprofen) in their Pure Form and Pharmaceutical Preparations

Abstract Micro‐drug estimation is performed on pseudoephedrine hydrochloride and ibuprofen macromolecules. The third‐order spectrum derivation technique revealed a linearity range of 20–50 µg/mL for both ibuprofen (Ibu) and pseudoephedrine (Psed). A uniform scaling factor of 10 is applied across all drugs. The limits of detection (LOD%) ranged from 0.12366 to 4.73181, and the limits of quantification (LOQ%) ranged from 0.370454 to 14.3388. The relative standard deviation (RSD%) values varied from 0.002779 to 0.020325, while the recovery (Rec%) values ranged between 96.8 and 100.734. Specifically, for ibuprofen and pseudoephedrine, the LOD% values are between 0.370454 and 14.3388, the RSD% values ranged from 0.005413 to 6.8824, and the Rec% values are observed within the range of 97.4719 to 104.487.